Going Pro to enhance T-cell immunogenicity: Easy as π?

The Effect of Easy-Going Steel on KBF's Seismic Behavior

The knee bracing steel frame (KBF) is a new type of energy dissipating frame which enjoys exceptional ductility and lateral stiffness. Rather than the beam-column joint, one end of the diagonal brace in KBF is attached to the knee element. Indeed, the knee element as a hysteretic damper is designed and detailed to behave like a structural fuse by sustaining controlled inelastic deformations as ...

The Effects of Using Easy-Going Steel Knee Element on Seismic Behavior of CKBF

A proper composition of stiffness and ductility parameters is required to obtain a resistant and economic structure. Accordingly, Chevron Knee Braced Frame (CKBF) seems appropriate due to its proper seismic performance. The advantage of this system comes to having the capability of rapid and cheap replacement of chevron knee elements after an earthquake occurs. In this research, response modifi...

Manipulating Immune Regulatory Pathways to Enhance T Cell Stimulation

T Cell Receptor Signals Enhance Susceptibility to Fas-mediated Apoptosis

Fas(CD95) and its ligand (FasL) interaction plays a pivotal role in T cell receptor (TCR)-mediated apoptosis. However, the susceptibility of T cells to Fas-mediated apoptosis is tightly regulated during immune responses, a regulation which is thought to maintain the antigen-specificity of T cell apoptosis. Here we show that TCR stimulation enhances the induction of Fas-mediated apoptosis. In ad...

TLR agonist rHP-NAP as an Adjuvant of Dendritic Cell-Based Vaccine to Enhance Anti-Melanoma Response

Background: Melanoma is a common and malignant cutaneous tumor, which is responsible for a large proportion of skin cancer deaths. Dendritic cell (DC)-based vaccines have achieved positive results in the treatment of melanoma because of their ability to induce cytotoxic response to facilitate tumor elimination. Objective: To improve the efficacy of dendritic ce...